Saturday, August 31, 2013

Study Confirms Resveratrol Anti-Aging Benefits

Harvard Medical School researchers say they confirm anti-aging benefits of resveratrol in a study published in Science on March 8, 2013. The study shows resveratrol stimulates production of SIRT1, a serum that blocks diseases by speeding up the cell's energy production centers known as mitrochondria. (Michelo 2013) Resveratrol is found naturally in Wine, Cocoa and Giant Knotweed is a common source for pure resveratrol supplements.

In other studies on resveratrol conducted in vivo and vitro, resveratrol displayed chemo preventive effects at three critical stages of carcinogenesis. Resveratrol has been found to induce phase II drug metabolizing enzymes (anti initiation); mediate anti inflammatory effects inhibiting cyclooxygenase and hydro-peroxidase (anti promotion); and induce human promyelocytic leukemia cell differentiation (anti progression).

Resveratrol is a powerful antioxidant which has also been shown to lower bad cholesterol, reduce the risk of blood clotting and has been reported to slow ageing by acting as a sirtuin activator.

Resveratrol can prolong both average and maximum lifespan. This has been proven in yeasts, roundworms, fruit flies, and a certain fish (see the diagram), and there is good reason to believe it will turn out to be true in mammals as well. (Will 2006)



References
Michelle Castilo. (2013, March 11), Reservatrol does provide anti-aging benefits, study shows. Retrieved from http://www.cbsnews.com/8301-204_162-57573590/resveratrol-does-provide-anti-aging-benefits-study-shows/

Will Block. (2006, August). Resveratrol—Star Molecule
Against Disease and Aging. Retrieved from http://www.life-enhancement.com/magazine/article/1729-resveratrol-star-molecule-against-disease-and-aging

2 comments:

  1. What is the optimal dose for a human?

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  2. "Recent findings on resveratrol’s effects in experimental animal models are attracting a great deal of interest from the scientific community, while raising many questions about resveratrol’s applications in humans. One of the most intriguing questions is what dose of resveratrol may help humans achieve the beneficial health effects that have been observed in animals. While extrapolating animal dosage to human dosage is difficult at best, scientists are using several approaches to address this question. The accumulating data from gene-expression studies in mice provide some clues. These findings are also helping to illuminate the molecular basis of the biological effects of resveratrol and grape extracts.

    The Harvard Study generated a great deal of enthusiasm by showing that mice fed high-fat diets (60% of calories from fat) avoided numerous diet-related health problems when supplemented with res-veratrol. Compared to mice that were not given resveratrol, the supplemented mice exhibited increased survival, increased insulin sensitivity, decreased organ pathology, and in-creased numbers of mitochondria.1 Resveratrol was also responsible for shifting the gene-expression patterns of mice on the high-fat diet towards those of mice on a standard (moderate-fat) diet. These results were achieved by feeding the mice a daily resveratrol supplement equivalent to 22.4 milligrams per kilogram of body weight.* In preliminary studies of this type, scientists often choose relatively high individual doses that are likely to generate an observable effect. Typically, more formal dose-ranging studies would be conducted later to identify optimal doses to attain specific effects. This is partly responsible for the controversy in the popular press regarding the relatively high dose of resveratrol used in this study.

    While the Harvard study was under way, BioMarker Pharmaceuticals had already completed an eight-week controlled feeding study in which mice received either resveratrol (a synthetic version) or grape extract (containing resveratrol and other constituents), along with a “normal” diet. Gene-expression profiles were completed on these animals and compared to those of a group of calorie-restricted mice. Genes affected by either resveratrol formulation (synthetic or natural grape extract) or by caloric restriction were then compared. Importantly, the resvera-trol dosage used in this study was much lower—approximately 12-fold lower—than that used in the Harvard study (see Table 1)."
    TABLE 1. RESVERATROL DOSAGE IN MICE
    Study
    Dose (mg/kg/day)
    Harvard study1 (high dose)
    22.4
    BioMarker study (low dose)
    1.45,a 1.74b
    a. Synthetic resveratrol
    b. Grape extract resveratrol (obtained from Grapeseed Extract with Resveratrol).
    Source: http://www.lef.org/magazine/mag2007/mar2007_report_resveratrol_04.htm

    Going by the Harvard Study, 22.4mg per kg provided significant benefits. So for a 150 pound person, they would weigh ~68kg. So a dose of 1.5g for would be the equivalent dose used in the Harvard Study. Although the BioMarker Study showed a dose which would be the equivalent of 115mg for a 150 pound person would provide benefits. So 200-500mg would probably be an ideal dose, with higher doses potentially providing greater benefits.

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